Clinical Long-Read Metagenomics: Precision Diagnostics for Sepsis via Virulome and Resistome Characterization
CLARIS
Medical microbiology must evolve beyond traditional genus and species identification to fully exploit the genomic information provided by Next-Generation Sequencing (NGS). Modern diagnostics require the characterization of virulence factors, resistance genes, plasmids, and transmission pathways to better understand pathogen behavior and clinical impact. Rapid NGS workflows can accelerate outbreak detection and investigation, enabling real-time genomic surveillance and more effective infection control strategies.
Open call
OC1 EIC Awardee + Buyer (wave2)
Sector
Healthcare
Buyer information
Hospital Clínic de Barcelona
Hospital Clínic de Barcelona (HCB) is a leading public university hospital and biomedical research institution in Spain. With more than 800 beds, it provides highly specialized healthcare, education, and research. Its Biomedical Diagnostic Center performs nearly 9 million laboratory analyses each year, supporting advanced diagnostics and innovation. The hospital is recognised for excellence in clinical care, translational research, and the development of precision medicine approaches.
Solver information
Sequentia Biotech
Sequentia Biotech is a bioinformatics SME with over a decade of experience translating omics data into actionable industrial and research applications. Backed by a team of bioinformaticians and bioinformatics developers, the company has delivered 900+ successful projects in genomics, metagenomics, transcriptomics, and epigenomics. Sequentia provides custom consulting and scalable cloud-based SaaS platforms across healthcare, agrifood, pharma and research sectors.
Solution
This pilot project aims to test a rapid precision diagnostic workflow using long-read Next-Generation Sequencing (NGS). The workflow is based on Sequentia Biotech’s proprietary bioinformatics ecosystem (SequentiaHub), combining two specialized modules: GAIA Clinical, for high-sensitivity taxonomic profiling in complex matrices, and PROKY, for genomic typing and resistome characterization.
Successful deployment will showcase how long-read NGS can transform clinical microbiology from descriptive taxonomy into high-resolution genomic epidemiology, enabling faster outbreak investigation, improved understanding of pathogen biology, and more precise diagnostics for infectious diseases.
Pilot specific details
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€123.4M
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38 SMEs
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60.000€
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50 Pilots
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Testimonials
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Name Surname
COMPANY
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Results
€123.4M
Lorem ipsum
38 SMEs
Lorem ipsum
60.000€
Lorem ipsum
50 Pilots
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Lorem ipsum dolor sit amet, consectetur adipiscing elit. Phasellus ligula elit, suscipit eget gravida ut, vehicula et quam. Nam dolor lectus, sollicitudin eget pulvinar ac, vestibulum sit amet leo. Cras ut lacinia purus. Ut vitae tincidunt elit, dignissim dignissim eros. Integer viverra imperdiet magna ac sodales. Phasellus tristique gravida justo, eget finibus enim egestas sit amet. Mauris maximus ligula sem. Morbi feugiat eget felis ac placerat. Aenean sit amet quam in dolor efficitur imperdiet vitae eu dolor.
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Phasellus ligula elit, suscipit eget gravida ut, vehicula et quam. Nam dolor lectus, sollicitudin eget pulvinar ac, vestibulum sit amet leo. Cras ut lacinia purus. Ut vitae tincidunt elit, dignissim dignissim eros. Integer viverra imperdiet magna ac sodales. Phasellus tristique gravida justo, eget finibus enim egestas sit amet. Mauris maximus ligula sem. Morbi feugiat eget felis ac placerat. Aenean sit amet quam in dolor efficitur imperdiet vitae eu dolor.
